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Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic

CEO Lars Fruergaard Jrgensen on Thursday acknowledged the sharp share price reaction after two consecutive late-stage trials showed underwhelming weight reduction versus the company's own targets, but said he nevertheless remained "encouraged" by the drug's weight loss profile

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Multiple reviewers describe medications that never arrived, were delivered late, or arrived damaged