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GoF receptors are often characterised by a greater propensity for G protein versus -arrestin recruitment and signalling, slower rate of receptor internalisation and rapid recycling back to the plasma membrane, with these characteristics being independent of their surface expression levels ( The GLP-1R has itself several LoF variants including R380C, shown by two independent groups to have normal surface expression but reduced affinity for Exenatide ( s proteins in response to various endogenous and clinical agonists ( 2+ mobilization (which is essential for insulin secretion)

These symptoms may indicate anaphylaxis, a medical emergency requiring prompt treatment with epinephrine