In test-tube studies, alpha-lipoic acid has reduced markers of inflammation, including NF-kB, ICAM-1, VCAM-1, MMP-2, MMP-9, and IL-6 ( May lower heart disease risk factors Heart disease is responsible for one in four deaths in America ( Research from a combination of lab, animal, and human studies has shown that the antioxidant properties of alpha-lipoic acid may lower several heart disease risk factors
During my residency, I encountered a patient who had been taking what he called his daily vitamin D megadose 50,000 IU every day for six months after reading online that more is better. He came to the emergency department with kidney stones and severe fatigue
Long term supplementation with cyanocobalamin can have systemic toxic effects on the body amd even lead to kidney failure
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