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A large number of studies have investigated peripheral metabolomic changes in the aforementioned conditions, with considerable overlap between PAIS, CFS, and immunometabolic depression: As reviewed by Komaroff et al., the systemic metabolomic changes in ME/CFS patients are characterized by (1) an impairment in the production of ATP from all energy substrates, (2) a general hypometabolic state and (3) an imbalance between pro- and antioxidant metabolites favouring pro-oxidant processes [43, 62]

No interaction between inositol and Wegovy is listed in the UK Summary of Product Characteristics (SmPC), and no published clinical interaction studies exist

This is particularly relevant in chronic tendinopathy, where the local repair response has stalled