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Histidine in health and disease: metabolism, physiological importance, and use as a supplement

doi: 10.1152/physrev.00032.2015 17 HlscherC

Alcohol use disorder (AUD) is the third-leading cause of preventable death in the United States, yet there are only three modestly effective drugs for treatment, the last one approved in 2006

Thus, the use of combination pharmacotherapy involving other molecules in addition to gut hormones seems to be a plausible approach to treating the metabolic syndrome