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In contrast, if metabolically competent human HepaRG cells [142] or primary human hepatocytes [46] were treated with 20 mM APAP for 24 h, there was 8090% GSH depletion, a ten-fold higher protein adducts formation, 7090% reduction of the mitochondrial membrane potential and 610-fold increase in LDH or ALT release

Among the various natural products, ubiquitous hydroxylated flavonoids have been documented as a potent inhibitor of tyrosinase due to their structural similarities with tyrosinase substrates, such as l-tyrosine and l-DOPA, and substantial antioxidant properties 11,29,30,31

Measuring acute postoperative pain using the visual analog scale: the minimal clinically important difference and patient acceptable symptom state