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High-dose ionizing radiation accelerates atherosclerotic plaque progression by regulating P38/NCOA4-mediated ferritinophagy/ferroptosis of endothelial cells

The most practical test is a careful low-dose trial with observation: take the supplement with food, document timing and symptoms, pause for several days to see if the headache resolves, and consult your clinician for severe or alarming symptoms

Br J Pharmacol 129:17551763 Lovric-Bencic M, Sikiric P, Hanzevacki JS et al (2004) Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse

On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon