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Specificity analyses also consistently indicated significant associations between GLP-1 RAs use and reduced risks in different composite adverse outcomes, further substantiating the robustness of our results (Figure S4)

Genomic DNA from these plants was extracted by Wizard Genomic DNA Purification Kit (Promega) and pooled together as one sample, which was used for DNBSEQ PE150 whole genome sequencing with 80X coverage

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Melanin pigment is also observed in melanophages in the upper portion of the lamina propria (13,14)