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Collectively, these findings underscore the important role of HIF-1 in mediating bone destruction in FLS of RA patients

23 These symptoms can be severe in some patients, resulting in a pause of dose escalation, and if intolerable GI symptoms continue, a dose adjustment to the previous lower dose or a switch to an alternative GLP-1 RA should be considered

Although further research is essential to investigate this potential causal relationship, caution is advised when prescribing GLP-1 RAs to patients with preexisting ocular risk factors [101]

In our study, we did not see an increased risk of NAION associated with dulaglutide