In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials
Other dangerous side effects include inflammation of the pancreas, serious allergic reactions, severe stomach problems, dehydration, changes in vision, gallbladder problems, kidney problems
Specifically, prolonged GLP-1RA administration (13 years or longer) has been associated with elevated thyroid cancer risk in certain populations [4], while high concentrations of liraglutide (100 nM) have been demonstrated to promote breast cancer progression via the NOX4/ROS/VEGF signaling pathway [18]
It turned out, however, that was nearly nine times the amount patients are typically told to take for their first dose