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Topicals can be effective for around 20-60 minutes, and Vyleesi content in the body peaks at around one hour before falling again.57 Even with combining Addyi and Vyleesi, there dont appear to be any known risks of mixing these two approaches together at the time of this writing

Schnenberger KA, et al

For clinicians and patients alike, safety is the first and most pressing concern, especially given the association of peptides with performance enhancement and off-label use