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It remains to be determined whether differences in barrier permeability are associated with comorbid anxiety or depression in GERD patients, which should be further validated through clinical data analysis and animal experiments to establish a causal link between metabolite-mediated barrier disruption and GERD comorbidities

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Women are more likely to suffer from bone fractures than men because they have smaller and thinner bones and the bone-protecting hormone estrogen decreases sharply during menopause, according to the Bone Health & Osteoporosis Foundation

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