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These include midodrine, an alpha-1 adrenergic agonist approved by the FDA for symptomatic orthostatic hypotension that induces vasoconstriction to increase peripheral resistance and standing blood pressure

[7] Once full, sharps bins should be returned to a designated NHS collection point and must never be placed in household recycling or general waste (NHS guidance on sharps disposal

These concerns highlight the need for the development of novel GLP-1R agonists that minimize these side effects while maintaining beneficial metabolic outcomes

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