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TBI activates ferroptosis, inflammation, and immune responses, mainly through microglia and macrophages, influencing TBI outcomes and offering therapeutic targets (Li and Jia, 2023)

Cerebrolysin vs Semax vs Cerebroprotein Hydrolysate Feature What it is Cerebrolysin Pig-brain peptide + amino acid mix Semax Short synthetic peptide Cerebroprotein hydrolysate Pig-brain protein hydrolysate Feature How given Cerebrolysin IV infusion or IM Semax Usually intranasal drops/spray Cerebroprotein hydrolysate IV or IM Feature Main idea Cerebrolysin Supplies repair-like signals Semax Nudges the body's own BDNF Cerebroprotein hydrolysate Similar hydrolysate concept Feature Note Cerebrolysin Most studied of the three Semax Different molecule and route Cerebroprotein hydrolysate Similar but not identical to Cerebrolysin These are different products with different evidence and routes

This effect may be related to the activation of AMP-activated protein kinase (AMPK) and sirtuin1 (SIRT1)/forkhead box O1 (FOXO1) pathway (Li et al., 2018