overdose of semaglutide GLP-1 overdoses have been skyrocketing, with poison centers seeing a nearly 1500% increase in calls related to or side effects injectable weight-loss drugs since 2019, according to US National Poison FDA alerts health care providers,

Avoid contamination during handling

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Theyre influenced by very real, very identifiable variables: Neurotransmitter balance, particularly dopamine signaling Hormonal status and age-related changes affecting CNS response Metabolic adaptation, including muscle mass and basal metabolic shifts Psychiatric history, where closer monitoring is appropriate Population-level data does not indicate increased suicidal ideation risk overall, but individualized care remains essential