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The loss of the chondrocytic phenotype and proliferative potential during in vitro expansion, termed as dedifferentiation, has been well documented
Non-surgical treatments can address a small amount of loose skin, but they have limitations
The Transmembrane Glycoprotein NMB (GPNMB) vaccine The expression of this transmembrane protein was found to be increased in aging (e.g., human mesenchymal stem cells from old donors) and in some age-related pathologies, such as osteoporosis 61