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For an in-depth description of the biology of GLP-1, readers are referred to a recent review by Figure 1)

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According to the MHRA/EMC SmPC, these include: Vomiting reported in approximately 8% of patients Abdominal pain and discomfort cramping or bloating may make it difficult to find a comfortable sleeping position Acid reflux or heartburn which can worsen when lying down Hypoglycaemia (low blood glucose) may occur, particularly when Ozempic is used in combination with sulphonylureas or insulin