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American Journal of Clinical Nutrition, 117 (4), 733-741

The patients who report the strongest response are those who are already active, eat well, and are looking to optimize cellular energy output rather than compensate for lifestyle gaps

272 Molecular biophysics also provides insights into the role of the extracellular matrix (ECM) in ligament healing

Reinforcing this, in heart failure with preserved ejection fraction, randomized trials such as the STEP-HFpEF program published in the New England Journal of Medicine demonstrated improvements in symptoms and physical limitations, with benefits that could not be fully explained by weight loss alone