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The smaller studies that make up a meta-analysis can sometimes show larger effects than in a single study that has a lot more participants

Metformin: an old but still the best treatment for type 2 diabetes

As with any treatment, its important to work closely with a healthcare professional to determine the best approach

However, antidepressants are still sometimes prescribed to help if patients are experiencing depression ( Treating comorbidities ME/CFS displays an overlap with several autoimmune or immune-mediated diseases that also have chronic fatigue as a main symptom, such as Hashimotos thyroiditis (530), fibromyalgia (FM) (532, 554557), Mast Cell Activation Disorder (532), sleep apnoea (532), IBS (532), secondary depression or anxiety (532), Ehlers-Danlos syndrome (532), and PoTS (532, 558563)