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For example, ferroptotic macrophages have the ability to generate HMGB1, a DAMP that triggers the release of pro-inflammatory cytokines, including IL-1 and IL-18, and activates the inflammasome (61)

Two participants experienced diarrhoea and abdominal cramping and the dose of metformin was decreased to 1500 mg daily

75 It elevates human brain GABA levels, possibly via alterations in GABA synthesis or reversal of the neuronal GABA transporter, resulting in nonvesicular release of GABA

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