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Key findings (PMID 36216945): GI side effects decreased over time most resolved by weeks 12-20 No new safety signals emerged between year 1 and year 2 Weight loss maintained at -15.2% at 2 years vs -2.6% with placebo 82.2% reported at least one GI event over 2 years, but the vast majority were early and transient Across the full SUSTAIN and PIONEER programs (11,159 patients with type 2 diabetes), the safety profile remained consistent with shorter-term data

Mitochondrial-Derived Peptide for Metabolic Research

Secretory IgA may prevent intestinal barrier dysfunction, possesses immunomodulatory properties and may play a role in inflammatory bowel diseases such as UC and Crohns

Published November 18, 2013