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APAP induces hepatotoxicity, attenuates lipid peroxidation, and enhances antioxidant enzyme activation, including increases in interleukin (IL)-1, IL-6, and tumor necrosis factor- elevated (Yen et al., 2008)

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In those experiments, pretreatment with the peptide enhanced subsequent responses to growth hormone stimulation, including increased cell viability, elevated proliferating cell nuclear antigen (PCNA) expression, and greater JAK2 phosphorylation activity [5]

Research is mixed, and supplementing with DHEA can be risky,7 but some studies suggest potential short-term, minor benefits (like improved feelings of well-being) in certain populations, such as older women with reduced natural DHEA levels.8 Ultimately, more research is needed before it can be said if DHEA supplementation is safe, particularly in the long term