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[DOI] [PubMed] [Google Scholar] 14.Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 randomized clinical trial

Sperm DNA fragmentation is a clinically validated predictor of pregnancy loss 51 , and its reduction from 8.3% (control) to 5.0% at 100 g/mL, approaching the 5% AI semen quality threshold, likely contributed to improved embryo survival following cervical insemination

This is significant for IVF because egg cells and embryos are very energy-hungry, and oxidative stress from free radicals can damage the DNA in eggs and sperm

However, grape-seed extract (GSPE) can help restore their expression