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A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice

Josephine Egan and colleagues teamed with Amylin Pharmaceuticals to begin preclinical testing of exendin-4

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However, and paradoxically, long-term glutaminolysis activation during nutritional restriction induces an unbalanced activation of mTORC1 during nutrient deprivation and promotes apoptosis [92]