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Patients should maintain a direct and open line of communication with their healthcare provider when taking Zepbound to ensure any concerns are addressed promptly and effectively

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However, when compared to endogenous GLP-1, exendin-4 has a C-terminal extended (CEX) amino acid sequence, along with substitution of the N-terminal alanine-2 residue with glycine, which makes the peptide resistant to degradation by DPP4, resulting in a significantly longer half-life than endogenous GLP-1 [62]

This meta-analysis aims to evaluate whether the effects of SGLT-2i or GLP-1 RAs on cardiovascular outcomes are consistent with and without baseline metformin use