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As described above for PABA/NO, JS-K, and GSNO, the NHGs, in accordance with GT expression patterns, contribute to chemotherapy by producing locally high levels of NO which can rapidly react with O 2 - to generate the potent oxidant peroxynitrite that, in turn causes extensive cellular damage, including the nitration of protein tyrosine residues (Kirsch et al., 2001)
Int J Mol Sci 23
Whether the lean mass preservation observed with combination liraglutide-plus-exercise translates to higher-magnitude weight loss on more potent agents is a question the published RCT literature has not yet definitively answered
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