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For signals to be sent from neuron to neuron, not only does the neurotransmitter have to be released into the synapse, but it also has to be received in a receptor, which then sets off a chain of events to send on the signal

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A preliminary analysis to determine the effects of 1 week of l-carnitine supplementation in cancer patients with fatigue and carnitine deficiency showed a significant improvement on fatigue, depression, and sleep disruption [22]