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Sometimes the solution is not more B12 but addressing what else is depleting it

Source: The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis (2021) Methyl B12 as a syrup showed promising improvements in individuals with autism, most likely because it improved oxidative status

As isolated as an air-stable solid and available commercially, cobalt in vitamin B 12 (cyanocobalamin and other vitamers) is present in its +3 oxidation state

The exception involves individuals with specific genetic variants in the MTHFR, MTR, or MTRR genes that impair B12 metabolism