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Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis

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doi: 10.1242/jeb.105890 58 MutalipassiM.MazzellaV.SchottM.FinkP.GlavianoF.PorzioL.et al

73 Studies 74 have shown that TNF- can amplify local inflammation by activating the NLRP3 inflammasome and inducing IL-1 secretion, while also binding to TNF-R1 on esophageal sensory neurons and activating the p38 MAPK pathway, thereby increasing the open probability of TRPA1 channels and enhancing mucosal sensitivity to refluxate