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In June 2025, MBX Biosciences announced that it has submitted an IND application to the FDA for MBX 4291, a long-acting GLP-1/GIP receptor co-agonist prodrug targeting obesity, which received regulatory clearance in July

2015 Feb 15;402:43-50

RNA isolation, cDNA synthesis, and quantitative RT-PCR H9c2, NMCMs, and hiPSC-CMs were collected into QIAzol Lysis Reagent or Trizol Reagent (Invitrogen) and total RNA was extracted using Direct-zol RNA Miniprep and Microprep (Zymo Research, CA, USA), respectively

These medications slow gastric emptying, increase insulin sensitivity, and reduce appetite, creating a powerful tool for weight management and blood sugar control