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Studies have shown that GLP-1RA administration decreases serum levels of inflammatory cytokines, improves hemodynamic parameters, and reduces mortality ( Figure 2 Figure 3 5 Effects of GLP-1 receptor agonists on biomarkers of inflammation In a systematic review and meta-analysis conducted by Bray et al., data from 40 randomized controlled trials were analyzed to examine the effects of GLP-1RAs on biomarkers of inflammation and oxidative stress in patients with type 2 diabetes

Observational data regarding risk for PDAC in humans from GLP-1 receptor agonism Data regarding risk of a specific adverse event following medication exposure comes from primary sources, which yield complementary information: post-marketing surveillance reports, clinical trials, and observational studies

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In the 2024 guidelines published by the ESC for PAD management, the authors do not mention GLP-1 RAs as part of management, likely due to limited data at the time [50]