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Tolerability also differs substantially, with at least one in three users experiencing adverse events, such as nausea, vomiting, diarrhoea or constipation, whereas others report minimal or no events

Endoplasmic reticulum (ER) stress is a secondary response caused by oxidative stress or inflammation mediated by aggregated proteins 14,15

As Novo prepares for critical clinical trial results due in December, the pressure is mounting, particularly after a 25% drop in stock value linked to lower-than-expected prescriptions for Wegovy and investor concerns (see chart below for drop marked)