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Among the recent cardiovascular safety outcomes trials testing DPP-4 inhibitors, the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus Thrombolysis in Myocardial Infarction 53 (SAVOR-TIMI 53) study evaluating saxagliptin demonstrated a significant increased risk of HF, with 3.5% risk of hospitalisation for HF vs 2.8% for placebo (HR 1.27

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tell your care team immediately if you develop hives, especially if you also have swelling of the mouth or throat or trouble breathing