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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies

Longer exposure, combined with full-dose maintenance after titration, produces substantially deeper weight loss

Bioavailability refers to how much of a substance actually enters your bloodstream and becomes available for your cells to use