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Regular physical activity : Successful weight maintainers typically engage in high levels of physical activityat least 200-300 minutes per week of moderate-intensity exercise (equivalent to 40-60 minutes 5 days weekly), plus resistance training
Weeks 4 to 8: If the approach is going to work, most patients begin seeing meaningful changes in this window
In February 2026, full results from the REDEFINE 2 study showed CagriSema achieving 23% weight loss at 84 weeks but falling short of its primary endpoint under the treatment policy estimand (which measures efficacy across all patients regardless of whether they completed treatment, rather than only those who remained on it)
When using the abdomen, it is important to stay at least two inches away from the belly button
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