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Interestingly, we observed minimal regulatory effects of expressed PGC1- directly on the FNDC5 promotor alone or with CREB (Supplementary Figure S3B), leading to no significant activation of luciferase expression

Goldsher D, Litt AW, Pinto RS, Bannon KR, Kricheff II

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In topical and experimental models, it has been studied for its ability to reduce fine lines and wrinkles, support firmer and more elastic skin, and promote a more even, lit-from-within complexion