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While IcoSema and basal-bolus insulin showed similar results for time in range, IcoSema had a lower percentage of participants below range (glucose below 54 mg/dL)

For example, mutations that affect the activity of mitochondrial persulfide dioxygenase (ETHE1, the enzyme in charge of GSSH degradation) are responsible for ethylmalonic encephalopathy, an inborn error of metabolism that leads to neurodevelopmental complications ( The electrophilicity of persulfides, absent in thiols and H 2 S/HS , is at the basis of their ability to transfer the sulfane sulfur to acceptor molecules

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The major obstacle in developing such therapies will be the ubiquitous presence of the UPS in eukaryotes which may require nanomedicine approaches or other tissue-targeting strategies to minimize adverse effects of such therapies