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Mouse model LOXL2+/ heterozygous mice on a C57Bl/6 background were produced by using cryopreserved sperm in which the Loxl2 gene was disrupted by insertion of a long terminal repeat-trapping cassette into exon 1 (Taconic Inc.)

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Animals receiving BPC-157 demonstrated accelerated functional recovery, increased collagen fiber organization, and enhanced biomechanical strength at the repair site compared to vehicle-treated controls (Staresinic et al., 2003, Journal of Orthopaedic Research