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Indeed, both tBHP and CHP greatly increased labile iron levels in cardiomyocytes as assessed by calcein-acetoxymethyl ester assay 32 (Fig

They may result from: 1) an inhibition of the homocysteine remethylation pathway that is a consequence of folate or vitamin B 12 deficiencies, or the presence of the thermolabile MTHFR mutation or a functional deficiency in methionine synthase