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We hope further studies shed more light on this complicated picture, he says
Indeed, glutamine-derived R-2-HG accumulates and prevents the differentiation of myeloblasts, resulting in uncontrolled growth of blood cells 122
For example, PRMT1 overexpression is associated with increased arginine methylation and aberrant exon inclusion of SRSF1, which is essential for breast cancer cell growth [47]
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