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11 Clinical Trials on Triple GLP-1/GIP/Glucagon Agonists Retatrutide: A Triple Agonist for Maximum Weight Loss Retatrutide (LY3437943) is a triple incretin receptor agonist targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors, and is designed to maximize weight loss and metabolic improvement through complementary hormonal pathways

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As your body adjusts to the medication and your nutrition improves, fatigue usually fades within a few weeks

The other trials, TRIUMPH-2 (type 2 diabetes) and TRIUMPH-3 (cardiovascular disease), will be out later this year