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We first conducted GWAS for GMV in the left vmPFC, rule-breaking scores and quantity of smoking at BL in the remaining subjects from the IMAGEN project ( n = 1026), who were not included in the above longitudinal analyses due to the lack of neuroimaging data at FU (see Methods for more details)

Certain variants incorporate enhanced filter structures (e.g., composite or high-density acetate filters) to regulate smoke delivery and improve filtration efficiency, while most standard versions do not rely on capsule-based systems

Data may suggest links between vaping and chronic lung disease and asthma, among other issues, that may seriously impact a persons health

Additional reporting by Manya Saini and Deborah Sophia in Bengaluru.