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Readers should weigh the recommendations with this context, noting that the underlying anatomical and mechanistic observations are independently corroborated by other sources

While NO is essential at physiological concentration, its overproduction has been associated with neurotoxicity, apoptosis, and extensive tissue damage across multiple organs [46, 47]

It's worth noting that tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist, representing a distinct but related medication class with similar clinical effects