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Serum Concentrations of Cotinine and Trans-3-Hydroxycotinine in US Adults: Results From Wave 1 (20132014) of the Population Assessment of Tobacco and Health Study Connie Sosnoff, Kevin Caron, J Akins, Kristin Dortch, Ronald Hunter, Brittany Pine, June Feng, Benjamin Blount, Yao Li, Bemmel van, Heather Kimmel, Kathryn Edwards, Maciej Goniewicz, Dorothy Hatsukami, Castro de, John Bernert, Stephen Arnstein, Nicolette Borek, Ying Deng-Bryant, Elena Mishina, Charles Lawrence, Andrew Hyland, Stephen Hecht, Kevin Conway, James Pirkle, Lanqing Wang Nicotine & Tobacco Research 7

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The new knowledge gained through this review provides the evidence for synergism between asbestos exposure and tobacco smoke in lung cancer causation at a biological level