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First, we progressively increased selection stringency by reducing labeling time (Fig
Gene expression depends on DNA accessibility, as DNA is tightly packaged in chromatin, wrapping around histone octamers composed of H2A, H2B, H3, and H4
Moreover, studies have shown that certain drugs and integrative interventions, such as the staple antidiabetic medication metformin and the natural phytochemical curcumin (found in the spice turmeric), may help overcome chemoresistance and sensitize some cancers to the toxic effects of chemotherapy (Soritau 2011
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