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Where feasible, mediation analyses should distinguish direct reproductive effects from those driven solely by weight loss

Edaravone slows down the loss of motor function in ALS patients by 33% compared to controls [Writing Group on Behalf of the Edaravone (MCI-186) ALS 19 Study Group, 2017a

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MMA can be treated with cobalamin injections on an individual basis, and long-term treatment includes the use of special formulas limiting the precursor substances of propionic acid (methionine-, valine-, threonine-, and isoleucine-free): high-calorie diets are provided to support growth and development, carnitine supplementation is recommended to promote organic acid excretion, and application of antibiotics can be used to reduce the intestinal flora