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689 With the consumption of GPX4, SLC7A11 and GSH, a significant increase in total iron and lipid peroxidation could be detected within 2 weeks

This creates challenges for the selection of relevant endpoints given that pharmacologic agents for the treatment of NASH and especially fibrosis have a low likelihood of inducing clinically significant improvements over this short time frame

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This pattern likely reflects your body's adaptation to the medication's presence rather than the drug wearing off