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Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic 7nAchR/JAK2/STAT3/NF-B pathway in rats exposed to chronic unpredictable mild stress

This intentional slowing of digestion creates the medication's weight-loss effect but also triggers mild nausea as your body adjusts to delayed stomach activity

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In addition, acute oral toxicity experiments in mice showed that compound 8u is non-toxic and can tolerate doses up to 2000 mg/kg (Zhang et al., 2019)