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Neurotrophic agents such as nerve growth factor and brain-derived neurotrophic factor have received research attention concerning their potential to treat AD but have not progressed to clinical trials due to their large size, inability to penetrate the blood-brain barrier (BBB), and the high cost of synthesis

In the metabolic formation, Hcy-thiolactone spontaneously reacts with protein lysine residues 12,13,16 and generates N-Hcy-protein

There was a total caloric increase of 33% when the calories from the alcohol were added

This has led to the more frequent use of hydroxychloroquine, which is similar in structure but less toxic