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The MAD evaluated doses ranging from 140 mg to 420 mg administered every 4 weeks on days 1, 29 and 57

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Based on another RCT, a single dose of B12 (500 g/d) or its combination with B1(300 mg/d), B6 (80 mg/d), and B9 (2mg/d) during 12 weeks had favorable effects on the frequency of headache attacks and migraine disability (73)